Endocrine Abstracts

Resistin is a recently discovered 12.5 kDa cysteine-rich secreted polypeptide first reported from rodent adipocytes and plays important role in the development of insulin resistance and obesity. Recently, many investigators have linked resistin to reproductive function. Resistin expression was observed in bovine and rat ovaries and showed that resistin modulate granulosa cells function such as steroidogenesis and proliferation, in basal state or in response to IGF-I in vit...

Resistin, a new 12.5 kDa cysteine-rich protein, which is specifically secreted by adipocytes and describe as a potential link between obesity and insulin resistance. Recently, resistin and PPARs receptors was found in reproductive tissue such as ovary and it was found that resistin modulate ovarian follicle function. Additionally, thiazolidinediones, such as rosiglitazone, a synthetic agonist of PPAR-γ down-regulated resistin expression in rodents. The aim of the study wa...